Changing the molecular profile of primary and metastatic breast cancer identified by Foundation One: case report
DOI:
https://doi.org/10.29289/2594539420210053Palavras-chave:
breast neoplasms, metastasis, biopsy, cytogenetic analysisResumo
Objective: To describe a case report of a patient who presented with bilateral breast cancer with progression to metastatic
disease, in which immunohistochemical profile of the primary and metastatic tumor was divergent. Methods: This was a study
with a descriptive narrative and reflective design, of the case report type, based on secondary data, with information and images
obtained from the electronic medical records of the MVSoul system used in the oncology center of a private hospital in the Federal
District in Brazil. Data collection was derived from the analysis of data and images of the electronic medical record. Case report:
A patient presented with bilateral metastatic breast cancer, and the primary and metastatic breast tumors showed a difference in
immunohistochemical profile. Accordingly, we highlight the rarity of the case, the need for biopsies of metastatic lesions because
of the molecular heterogeneity of breast cancer and possible discrepancy between the primary tumor and metastases. Spreading
knowledge about diagnostic tests and personalized treatment according to tumor molecular characteristics is also essential,
especially when the patient does not have a satisfactory therapeutic response, as in the reported case, since the patient had
metastases with different molecular profiles confirmed only by of tumor DNA sequencing.
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Copyright (c) 2026 Izabella Fernandes Viana Montechi, Patrícia Werlang Schorn, Amanda Damazio Cabral, Juliana Sinezio Santos, Alessandra Vanessa Leite e Silva
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
