Article of the month

Two-stage risk-reducing breast surgery with a synthetic matrix: a case report

Andre Mattar et al. Two-stage risk-reducing breast surgery with a synthetic matrix: a case report. Mastology. 2026;36:e20260012. https://doi.org/10.29289/2594539420260012

As indications for risk-reducing mastectomy continue to expand among women with hereditary cancer syndromes, reconstructive strategies that maintain oncologic safety while improving aesthetic outcomes have become increasingly relevant.

This case report presents an innovative staged approach for patients with large, ptotic breasts, a population in whom nipple-sparing mastectomy is often technically challenging and associated with higher complication rates.

By describing the rationale, technical considerations, and early clinical outcomes of this procedure, the authors provide practical insights into an area in which evidence remains limited. The report emphasizes the importance of individualized surgical decision-making in hereditary breast cancer and supports further investigation of staged reconstructive approaches through larger prospective studies.