Integrative review on breast cancer screening in the transgender population: what do we know?
DOI:
https://doi.org/10.29289/2594539420210051Palavras-chave:
transgender persons, early detection of cancer, breastResumo
The lack of formal breast cancer screening guidelines for the transgender population and the unpreparedness of health
professionals to provide adequate health care to this population are described in the literature. The objective of this integrative
review was to present the proposals for breast cancer screening in the transgender population, based on the literature, being
searched in the Medline, PubMed, SciELO, and Lilacs databases. The articles that addressed breast cancer screening in the
female and/or male transgender population were selected, in addition to the associated studies with the use of hormone
therapy and breast cancer in transgender people, using the terms such as “transgender people,” “early cancer diagnosis,”
and “breast.” Of the 38 articles selected, 24 address recommendations for breast cancer screening in the female and/or male
transgender population. There is limited population-based information on mammography screening in transgender people,
which ultimately affects the analysis of cancer incidence in this population. The literature supports screening in the male
transgender profile (similar to the female cisgender). In transgender females, recommendations are implemented based on
expert’s opinions, such as mammographic screening after 5 years of hormone use. More studies on this subject are needed.
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Referências
1. Brazil. Ministério da Saúde. Rastreamento. Série A. Normas e Manuais Técnicos Cadernos de Atenção Primária, n. 29. Brasília: Ministério da Saúde, 2010.
2. Urban LABDU, Schaefer MB, Duarte DL, Santos RP, Maranhão NMA, Kefalas AL, et al. Recomendações do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, da Sociedade Brasileira de Mastologia e da Federação Brasileira das Associações de Ginecologia e Obstetrícia para rastreamento do câncer de mama por métodos de imagem. Radiol Bras. 2017;50(4):244-9. https://doi.org/10.1590/S0100-39842012000600009
3. Oliveira DAL. Políticas de saúde e diagnóstico precoce do câncer de mama no Brasil. Rev Enferm Digit Cuid Promoção Saúde. 2019;4(1):46-50. https://doi.org/10.5935/2446-5682.20190009
4. Hasset MJ, Somerfield MR, Baker ER, Cardoso F, Kansal KJ, Kwait DC, et. al. Management of male breast cancer: ASCO Guideline. J Clin Oncol. 2020;38(16):1849-63. https://doi.org/10.1200/JCO.19.03120
5. Spizzirri G, Eufrásio R, Lima MCP, Nunes HRCD, Kreukels BPC, Steensma TD, et al. Proportion of people identified as transgender and non-binary gender in Brazil. Sci Rep. 2021;11:2240. https://doi.org/10.1038/s41598-021-81411-4
6. Sociedade Brasileira de Endocrinologia e Metabologia (SBEM). Posicionamento Conjunto Medicina Diagnóstica inclusiva: cuidando de pacientes transgênero. Rio de Janeiro: Sociedade Brasileira de Patologia Clínica Medicina Laboratorial e Colégio Brasileiro de Radiologia e Diagnóstico por Imagem [Internet]. [cited on Jan 01, 2019]; 2019. Available from: https://www.endocrino.org.br/media/pdfs_documentos/posicionamento_trangenero_sbem_sbpcml_cbr.pdf
7. Pratt-Chapman ML, Ward AR. Provider recommendations are associated with cancer screening of transgender and gender-nonconforming people: a cross-sectional urban survey. Transgend Health. 2020;5(2):80-5. https://doi.org/10.1089/trgh.2019.0083
8. Puechl AM, Russel K, Gray BA. Care and cancer screening of the transgender population. J Womens Health 2019;28(6):761-8. https://doi.org/10.1089/jwh.2018.6945
9. Gibson AW, Radix AE, Maingi S, Patel S. Cancer care in lesbian, gay, bisexual, transgender and queer populations. Future Oncol. 2017;13(15):1333-44. https://doi.org/10.2217/fon-2017-0482
10. Bazzi AR, Whorms DS, King DS, Potter J. Adherence to mammography screening guidelines among transgender persons and sexual minority women. Am J Public Health. 2015;105(11):2356-8. https://doi.org/10.2105/AJPH.2015.302851
11. Phillips J, Fein-Zachary VJ, Mehta TS, Littlehale N, Venkataraman S, Slanetz PJ. Breast imaging in the transgender patient. AJR Am J Roentgenol. 2014;202:1149-56. https://doi.org/10.2214/AJR.13.10810
12. Charkhchi P, Schabath MB, Carlos RC. Modifiers of cancer screening prevention among sexual and gender minorities in the behavioral risk factor surveillance system. J Am Coll Radiol. 2019;16(4 Pt B):607-20. https://doi.org/10.1016/j.jacr.2019.02.042
13. Eneros AA, Zamorano SJ, Salazar RR, Lagos MAC. Terapia Hormonal en la Transición Masculino a Femenino (MTF) ó transexual femenino o régimen de feminización: parte II. Rev Soc Chil Obstet Ginecol Infant Adolesc. 2017;24(1):18-27.
14. Braun H, Nash R, Tangpricha V, Brockman J, Ward K, Goodman M. Cancer in transgender people: evidence and methodological considerations. Epidemiol Rev. 2017;39(1):93-107. https://doi.org/10.1093/epirev/mxw003
15. Deutsch MB, Radix A, Wesp L. Breast Cancer screening, management, and a review of case study literature in transgender populations. Semin Reprod Med. 2017;35(5):434-41. https://doi.org/10.1055/s-0037-1606103
16. Stone JP, Hartley RL, Temple-Oberle C. Breast cancer in transgender patients: A systematic review. Part 2: Female to Male. Eur J Surg Oncol. 2018;44(10):1463-8. https://doi.org/10.1016/j.ejso.2018.06.021
17. Price S, McManus J, Barrett J. The transgender population: improving awareness for gynaecologists and their role in the provision of care. Obstet Gynaecol. 2019;21(1):11-20. https://doi.org/10.1111/tog.12521
18. Nikolić D, Granić M, Ivanović N, Zdravković D, Nikolić A, Stanimirović V, et al. Breast cancer and its impact in male transsexuals. Breast Cancer Res Treat. 2018;171(3):565-9. https://doi.org/10.1007/s10549-018-4875-y
19. Sonnenblick EB, Shah AD, Goldstein Z, Reisman T. Breast imaging of transgender individuals: a review. current radiology reports. 2018;6(1):1-12. https://doi.org/10.1007/s40134-018-0260-1
20. Chotai N, Tang S, Lim H, Lu S. Breast cancer in a female to male transgender patient 20 years post‐mastectomy: issues to consider. Breast J. 2019;25(6):1066-70. https://doi.org/10.1111/tbj.13417
21. Schmidt M, Ditrio L, Shute B, Luciano D. Surgical management and gynecologic care of the transgender patient. Curr Opin Obstet. Ginecol. 2019;31(4):228-34. https://doi.org/10.1097/GCO.0000000000000553
22. Parikh U, Mausner E, Chhor CM, Gao Y, Karrington I, Heller SL. Breast imaging in transgender patients: what the radiologist should know. Radiographics. 2020;40(1):13-27. https://doi.org/10.1148/rg.2020190044
23. Schmidt E, Rizzolo D. Disease screening and prevention for transgender and gender-diverse adults. JAAPA. 2017;30(10):11-6. https://doi.org/10.1097/01.JAA.0000524709.87224.57
24. Stewart T, Lee YA, Damiano EA. Do transgender and gender diverse individuals receive adequate gynecologic care? An analysis of a rural academic center. Transgend Health. 2020;5(1):50-8. https://doi.org/10.1089/trgh.2019.0037
25. Li JZ, Tu HYV, Avram R, Pinthus J, Bordeleau L, Hodgson N. Cancer prevention and screening in a BRCA2-positive male to female transgender patient. Breast J. 2018;24(6):1112-3. https://doi.org/10.1111/tbj.13096
26. Eismann J, Heng YJ, Fleischmann-Rose K, Tobias AM, Phillips J, Wulf GM, et al. Interdisciplinary management of transgender individuals at risk for breast cancer: case reports and review of the literature. Clin Breast Cancer. 2019;19(1):e12-9. https://doi.org/10.1016/j.clbc.2018.11.007
27. Kiely D. Transgender patient screening: breast cancer risk assessment and screening recommendations. Clin J Oncol Nurs. 2017;21(3):E67-70. https://doi.org/10.1188/17.CJON.E67-E70
28. Patel JM, Dolitsky S, Bachman GA, Meritens AB. Gynecologic cancer screening in the transgender male population and its current challenges. Maturitas. 2019;129:40-4. https://doi.org/10.1016/j.maturitas.2019.08.009
29. Blok CJ, Wiepjes CM, Nota NM, van Engelen K, Adank MA, Dreijerink KM, et. al. Breast cancer risk in transgender people receiving hormone treatment: nationwide cohort study in the Netherlands British Medical Journal. BMJ. 2019; 365:l1652. https://doi.org/10.1136/bmj.l1652
30. Narayan A, Lebron-Zapata L, Morris E. Breast cancer screening in transgender patients: findings from the 2014 BRFSS survey. Breast Cancer Res Treat. 2017;166(3):875-9. https://doi.org/10.1007/s10549-017-4461-8
31. Hartley RL, Stone JP, Temple-Oberle C. Breast cancer in transgender patients: a systematic review. Part 1: male to female. Eur J Surg Oncol. 2018;44(10):1455-62. https://doi.org/10.1016/j.ejso.2018.06.035
32. Pivo S, Montes J, Schwartz S, Chun J, Kiely D, Hazen A, et al. Breast cancer risk assessment and screening in transgender patients. Clin Breast Cancer. 2017;17(5):e225-7. https://doi.org/10.1016/j.clbc.2016.08.003
33. Kiran T, Davie S, Singh D, Hranilovic S, Pinto AD, Abramovich A, et al. Cancer screening rates among transgender adults: cross-sectional analysis of primary care data. Can Fam Physician. 2019;65(1):e30-7. PMID: 30674526
34. Sterling J, Garcia MM. Cancer screening in the transgender population: a review of current guidelines, best practices, and a proposed care model. Transl Androl Urol. 2020;9(6):2771-85. https://doi.org/10.21037/tau-20-954
35. Labanca T, Mañero I, Pannunzio M. Transgender patients: considerations for routine gynecologic care and cancer screening. Int J Gynecol Cancer. 2020;30(12):1990-6. https://doi.org/10.1136/ijgc-2020-001860
36. Fledderus AC, Gout HA, Ogilvie AC, van Loenen DKG. Breast malignancy in female-to-male transsexuals: systematic review, case report, and recommendations for screening. Breast. 2020;53:92-100. https://doi.org/10.1016/j.breast.2020.06.008
37. Brown GR. Breast cancer in transgender veterans: a ten-case series. LGBT Health. 2015;2(1):77-80. https://doi.org/10.1089/lgbt.2014.0123
38. Donati CA, Nagelberg A. Screening mamário em pacientes transgénero bajo tratamento hormonal cruzado (THC). Situación actual y controvérsias. Rev Argent Mastología. 2019;38(137):116-32.
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Copyright (c) 2026 Maria Julia Gregorio Calas, Rebeca Fernandes de Azevedo Dantas, Carolina Bantim Ciscotto, Bruna Galper, Ingrid Meira Lopes de Carvalho, Juliana Moreira Guerra
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
