De novo gastric metastasis from invasive lobular carcinoma of the breast: report of three cases and literature review

Authors

DOI:

https://doi.org/10.29289/2594539420220016

Keywords:

gastric metastasis, breast neoplasms, invasive lobular carcinoma, ultrasound, magnetic resonance imaging, 18F-FDG PET/CT

Abstract

Abstract: Invasive lobular carcinoma is the second most common subtype of invasive breast cancer and presents with an unusual metastatic pattern. Its gastric metastasis mimics primary adenocarcinoma and the differentiation between them is difficult but primordial for proper treatment. The aim of this study is to report three cases of de novo Invasive lobular carcinoma of the breast, diagnosed with gastric metastasis at presentation. Neither of the patients complained about breast symptoms before the diagnosis. The final diagnosis was made only by comparing breast and gastric samples.

Downloads

Download data is not yet available.

References

Inoue M, Nakagomi H, Nakada H, Furuya K, Ikegame K, Watanabe H, et al. Specific sites of metastases in invasive lobular carcinoma: a retrospective cohort study of metastatic breast cancer. Breast Cancer. 2017;24(5):667-72. https://doi.org/10.1007/s12282-017-0753-4

Clinton LK, Plesec T, Goldblum JR, Hajifathalian K, Downs-Kelly E, Patil DT. Specific histopathologic features aid in distinguishing diffuse-type gastric adenocarcinoma from metastatic lobular breast carcinoma. Am J Surg Pathol. 2020;44(1):77-86. https://doi.org/10.1097/PAS.0000000000001341

El-Hage A, Ruel C, Afif W, Wissanji H, Hogue JC, Desbiens C, et al. Metastatic Pattern of Invasive Lobular Carcinoma of the Breast — Emphasis on Gastric Metastases. Journal of Surgical Oncology. 2016;114(5):543-47. https://doi.org/10.1002/jso.24362

Reed AEM, Kutasovic JR, Lakhani SR, Simpson PT. Invasive lobular carcinoma of the breast: morphology, biomarkers and ’omics. Breast Cancer Research. 2015;17(1):12. https://doi.org/10.1186/s13058-015-0519-x

Eo WK. Breast cancer metastasis to the stomach resembling early gastric cancer. Cancer Res Treat. 2008;40(4):207-10. https://doi.org/10.4143/crt.2008.40.4.207

Dória MT, Maesaka JY, Martins Filho SN, Silveira TP, Boufellia G, Siqueira SAC, et al. Gastric metastasis as the first manifestation of an invasive lobular carcinoma of the breast. Autopsy and Case Reports. 2015;5(3):49-53. https://doi.org/10.4322/acr.2015.018

Hong J, Kim Y, Cho J, Lim SW, Park SE, Kim HK, et al. Clinical features and prognosis of breast cancer with gastric metastasis. Oncology letters. 2019;17(2):1833-41. https://doi.org/10.3892/ol.2018.9754

Yagi Y, Sasaki S, Yoshikaw A, Tsukioka Y, Fukushima W, Fujimura T, et al. Metastatic gastric carcinoma from breast cancer mimicking primary linitis plastica: a case report. Oncology Letters. 2015;10:3483-7. https://doi.org/10.3892/ol.2015.3788

Pectasides D, Psyrri A, Pliarchopoulou K, Floros T, Papaxoinis G, Skondra M, et al. Gastric metastases originating from breast cancer: repost of 8 cases and review of the literature. Anticancer Research. 2009;29(11):4759-64. PMID 20032432.

Taal B, Peterse H, Boot H. Clinical presentation, endoscopic features and treatment of gastric metastases from breast carcinoma. Cancer. 2000;89(11):2214-21. https://doi.org/ 10.1002/1097-0142(20001201)89:11<2214::AID-CNCR9>3.0.CO;2-D

Jones GE, Strauss DC, Forshaw MJ, Deere H, Mahedeva U, Mason RC, et al. Breast cancer metastasis to the stomach may mimic primary gastric cancer: report of two cases and review of literature. World Journal of Surgical Oncology. 2007;5:75. https://doi.org/10.1186/1477-7819-5-75

Wong YM, Jagmohan P, Goh YG, Putti TC, Ow SGW, Thian YL, et al. Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review. Insights Imaging. 2021;12(1):181. https://doi.org/10.1186/s13244-021-01120-4

Xu L, Liang S, Yan N, Zhang L, Gu H, Fei X, et al. Metastatic gastric cancer from breast carcinoma: a report of 78 cases. Oncology Letters. 2017;14:4069-77. https://doi.org/10.3892/ol.2017.6703

Downloads

Published

2026-04-17

How to Cite

Suerdieck, J. G., Souza, J. A., Mattioni, M., & Bitencourt, A. G. V. (2026). De novo gastric metastasis from invasive lobular carcinoma of the breast: report of three cases and literature review. Mastology, 32. https://doi.org/10.29289/2594539420220016

Issue

Section

Case Reports