Aspectos clínicos, anatomopatológicos, recidiva local e sobrevida de pacientes com carcinoma de mama tratadas pela cirurgia conservadora
Clinical aspects, histologic findings, local recurrence and survival rates in patients with breast cancer treated with breast conservation surgery
Palavras-chave:
Neoplasias mamárias, Tratamento, Cirurgia conservadora da mama, Recidiva local de neoplasia, SobrevivênciaResumo
Objetivos: Avaliar a idade, o diâmetro do tumor primário, o estadiamento clínico, o tipo histológico, as porcentagens de recidiva local e a sobrevida de pacientes submetidas a tratamento conservador do carcinoma invasivo inicial de mama na Universidade Federal de São Paulo (Unifesp).
Métodos: Estudou-se, retrospectivamente, o prontuário de pacientes com câncer de mama submetidas a tratamento conservador, isto é, quadrantectomia com dissecção axilar e radioterapia, no
período de 1990 a 2002 na disciplina de Mastologia do Departamento de Ginecologia da Unifesp.
Avaliou-se a idade, o diâmetro tumoral, o estadiamento clínico e as taxas de sobrevida e recidiva
local. Resultados: A idade variou de 23 a 88 anos, sendo a média de 53,7 anos. O diâmetro do
tumor primário variou de 0,5 a 4 cm, sendo a média de 1,9 cm; 60,1% das pacientes estavam
no estádio clínico I; 34,4% no estádio IIA; 4,9% no IIB e 0,6% no III. O tipo histológico mais
freqüente foi o ductal infiltrativo (83,1%), seguido do lobular (7,1%). A recidiva local foi diagnosticada em 3,9% das pacientes e a sobrevida global no período médio de 44,5 meses foi de 97,3%.
Conclusões: A cirurgia conservadora no câncer de mama inicial apresenta resultados semelhantes
aos da cirurgia radical e os resultados do presente estudo foram comparáveis aos da literatura.
Downloads
Referências
1. Benda RK, Mendenhall NP, Lind DS, Cendan JC, Shea BF, Richardson LC, et al. Breast conserving therapy (BCT) for early stage breast cancer. J Surg Oncol. 2004;85:14-27.
2. Veronesi U, Saccozzi R, Del Vecchio M, Banfi A, Clemente C, De
Lena M, et al. Comparing radical mastectomy with quadrantecсtomy, axillary dissection, and radiotherapy in patients with small
cancers of the breast. N Engl J Med. 1981;305:6-11.
3. Salvadori B, Veronesi U. Conservative methods for breast cancer of
small size: the experience of the National Cancer Institute, Milan
(1973-1998). Breast. 1999;8:311-4.
4. Fisher B, Anderson S, Redmond CK, Wolmark N, Wickerham
DL, Cronin WM. Reanalysis and results after 12 years of follow
up in a randomized clinical trial comparing total mastectomy with
lumpectomy with or without irradiation in the treatment of breast
cancer. N Engl J Med. 1995;333:1456-61.
5.
6.
Jacobson JA, Danforth DN, Cowan KH, d'Angelo T, Steinberg
SM, Pierce L, et al. Ten year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast
cancer. N Engl J Med. 1995;332:907-11
Van Dongen JA, Bartelink H, Fentiman IS, Lerut T, Mignolet
F, Olthuis G, et al. Factors influencing local relapse and survival
and results of salvage treatment after breast conserving therapy in
operable breast cancer: EORTC trial 10801, breast conservation
compared with mastectomy in TNM Stage I and II breast cancer.
Eur J Cancer. 1992;28A:801-5.
7. Arriagada R, Le MG, Rochard F, Contesso G. Conservative treatment versus mastectomy in early breast cancer: patterns of failure
with 15 years of follow up data. Institute Gustave Roussy Breast
Cancer Group. J Clin Oncol. 1996;14:1558-64.
8. Morrow M, Strom EA, Basset LW, Dershaw DD, Fowble B. Giuliano A, et al. Standard for breast conservation therapy in the
management of invasive breast carcinoma. CA Cancer J Clin.
2002:52:277-300.
9. Kalbfleisch JD, Prentice RL. The statistical analysis of failure time
data. New York: Wiley Series in Probability and Satistics; 1980.
10. Agresti A. An introduction to categorical data analysis. New York:
John Wiley and Sons; 1996.
11. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini
12.
A, et al. Twenty-year follow up of a randomized study comparing
breast conserving surgery with radical mastectomy for early breast
cancer. N Engl J Med. 2002;347:1227-32.
Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher
ER, et al. Twenty year follow up of a randomized trial compаring total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med.
2002:347:1233-41.
13. Veronesi U, Del Vecchio M, Manzari A, Andreola S, Greco M,
Luini A, et al. Local recurrences and distant metastases after conservative breast cancer treatments: partly independent events. J
Natl Cancer Inst. 1995;87:19-27.
14. Veronesi U, Salvadori B, Luini A, Greco M, Saccozzi R, del Vecchio M, et al. Breast conservation is a safe method in patients with
small cancer of the breast. Long term results of three randomized
trials on 1,973 patients. Eur J Cancer. 1995;31A:1574-9.
15. Poggi MM, Danforth DN, Sciuto LC, Smith SL, Steinberg SM,
Liewehr DJ, et al. Eighteen-year results in the treatment of early
breast carcinoma with mastectomy versus breast conservation therapy: The National Cancer Institute Randomized Trial. Cancer.
2003;98:697-702.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2026 Amanda Neves Machado, Gil Facina, Luiz Henrique Gebrim

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.






