Clinical and psychological characteristics of women with moderate to severe mastalgia treated with gamma linolenic and linoleic acids
Keywords:
Cydic mastalgia, Polyunsaturated acids, TherapyAbstract
To evaluate response of moderate to severe cydic mastalgia to treatment with gamma
iinoienic and linoleic acids (EFA), using Cardiff Breast Score (CBS), within a non randomized
clinicai triai, an anaiysis was made of 30 patients, seen at the Mastology Outpatient C/inic of
Oswaido Cruz University Hospital from February, 2001 to July, 2002. Patients received verbal
advice and began treatment with EFA for three months. CBS degrees of response to treatment
were determined according to mastalgia eva/uation byana/og visual scaie (AVS). At the end of
treatment, 22 (73.3%)patients were responsive and 8 (26.7%)provedunresponsive. A/though
there was no statistical associa tion, it was found that women o ver the age of29, with mastalgia
of/ess than six years'duration, menarche before 13, non-nuliiparous, firstparturition over the
age of22 and up to six months' iactation; patients who stated it was not their first visit to the
mastologist as those who regarded themselves as irrita ted, depressed or stressed beca use of
mastalgia, most frequentiy experienced a complete or partia! reduction in pain after treatment.
The condusion was that EFA appeared to be effective in cydic breast pain and to be a good
choice as a flrst-line drug.
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References
1.ADER DN, BROWNE MW. Prevalence and
impact of cyclic mastalgia in a United
States clinic sample. Am J Obstet
Gynecol 1997; 177(1): 126-32.
2.ADER DN, SOUTH-PAUL J, ADERA T, DEUSTER PA. Cyclical mastalgia:
prevalence and associated health and
behavioral factors. J Psychosom Obstet
Gynaecol 2001; 22(2): 71-6.
3.BARROS ACSD, MOTTOLA D, RUÍZ CA,
PINOTTIJA. Tratamento da mastalgia com
alterações funcionais benignas das ma- mas. Revista do Centro de Referência de
Saúde da Mulher 1997; 2(2): 82-5.
4.BARROS ACSD, NAZÁRIO ACP. Alterações
funcionais benignas das mamas. In
Barros ACSD, Silva HMS, Dias E N, Nazário ACP, Figueira Filho ASS. Mastologia: condutas. Rio de Janeiro:
Revinter. 1999; 28-33.
5.BELIEU RM. Mastodinia. In: Marchant
DJ. Clínicas obstétricas e ginecológicas da América do Norte: tratamento
atual das doenças da mama I: doença
benigna. Rio de Janeiro: Interlivros.
1994; 471-88.
6.BRASIL - CONSELHO NACIONAL DE SAÚ- DE. Resolução 196/96. Brasília: DOU
1996.
7.CATALIOTTI L, BIANCHI S, CIATTO S. Patologia mamária benigna. In: Veronesi
U, Luini A, Costa A, Andreoli C. Mastologia oncológica. Rio de Janeiro: Medsi. 2002; 171-8.
8.CHEUNG KL. Management of cyclical
mastalgia in oriental women; pioneer
experience of using gamolenic acid
(EFAMAST) in Asia. J Surg 1999; 69(7):
492-94.
9.DAVIES EL, GATELEY CA, MEIRS M, MANSEL RF. The long term course of mastalgia. J Soe Med 1998; 91(9):
462-4.
10.DOWNEY HM, DEADMAN JM, DAVIS C,
LEINSTERSJ. Psychological characteristics
of women with cyclical mastalgia. Breast Dis 1993; 6: 99.
11.ECOCHARD R, MARRET H, RABILLOUD M, BOEHRINGER H, MATHIEU C, GUERIN
JF. Gonadotropin leveis abnormalities in women with cyclic mastalgia. Eur J Obstet Gynecol 2001; 94(1): 92-6.
12.ENDICOTT J. History, evolution and
diagnosis of pre-menstrual dysphoric in
the obstetric, gynecologtc and primary
care practice. J Clin Psychiatric 2000;
61(suppl): 5-8.
13.FENTIMAN IS. Tratamento da dor ma- mária. In: Herris JR, Lippman ME, Morrow M, Osborne CK. Doenças da mama. 2! ed. Rio de Janeiro: Medsi.
2002; 65-71.
14.FIGUEIRA ASS, ARAÚJO R, SANTOS ALG, RAMALHO EH, PETRILLI A. Uso
do ácido gamalinolênico em pacientes
portadoras de mastalgia. Congresso
Luso-Brasileiro de Mastologia. III. Recife; 1996.
15.GATELEY CA, BUNDRED NJ, WEST RR, MANSEL RE. Reproductive factors
associated with mastalgia. Câncer
Detect Prev 1992; 16(1): 39-41.
16.GATELEY CA, MADDOX PR, PRITCHARD
GA et at. Plasma fatty acid profile in
benign disorders. Br J Surg 1992; 79:
407-9.
17.GATELEY CA, MEIRS M, Mansel RE, HUGHES LE. Drug treatments formastalgia: 17 years experience in the
Cardiff mastalgia clinic. J R Soe Med
1992; 85(1): 12-5.
18.HADI MSAA. Sports Brassiere: is it a
solution for mastalgia? The Breast
Journal 2000; 6(6): 407-9.
19.HOLLAND PA, GATELEY CA. Drug therapy
of mastalgia. What are the options? Drugs 1994; 48(5): 709-16.
20.HUGHES LE, MANSEL RE, WEBSTER DJT. Breast pain and nodularity. In: Benign
disorders and diseases of the breast
concepts and clinicai management. 2nú
ed. WB Saunders. 2000; 95-121.
21.MENKE CH, BIAZÚS JV, CAVALHEIRO JA, RABIN EG. Alterações funcionais benignas da mama. In: Franco
JM. Mastologia, formação do especialista. São Paulo: Atheneu. 1997;
77-85.
22.PADDEN DL. Mastalgia: evaluation and management. Fértil Steril 2001; 75(4):
718-23.
23.PREECE PE, HANSLIP JI, GILBERT L et
al. Evening primrose oil (Efamol) for mastalgia. In Horrobin DF. (ed.). Clinicai uses of essential fatty acids. Montreal: Eden Press. 1982; 147-54.
24.PYE JK, MANSEL RE, HUGHES LE. Clinicai
experience of drug treatments for mastalgia. Lancet 1985; 2(8451): 373-
7.
25.RAMIREZ AJ, JARRET SR, HAMED H,
SMITH P, FENTIMAN IS. Psychosocial
adjustment of women with mastalgia.
The Breast 1995; 4: 48-51.
26.SHARMA AK, MISHRA SK, SALILA M, RAMECH V, BAL S. Cyclical mastalgia:
is ita manifestation ofaberration in lipid metabolism? Indian J Physiol Pharmacol
1994; 38(4): 267-71.
27.SILVA HMS. Alterações funcionais benignas da mama: como eu trato. GO
Atual 1997; (8): 45-6.
28.SOUBA WW. Tratamento das doenças
benignas da mama. Avaliação e trata- mento das doenças benignas da mama.
In: Bland Kl, Copeland III EM. A mama:
tratamento compreensivo das doenças
benignas e malignas. São Paulo: Manole.
1994; 816-20.
29.WORLD HEALTH ORGANIZATION -
Centers for Disease Control and
Prevention. EPI-INF0 6.04d, 14/01/2001.
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