907 – Do surgical techniques influence survival in early breast cancer? A retrospective cohort study of 1,517 patients in Brazil

Authors

  • Natalie Rios Almeida Universidade Estadual de Campinas – Campinas (SP), Brazil.
  • Nicoli Serquiz de Azevedo Universidade Estadual de Campinas – Campinas (SP), Brazil.
  • Fabricio Palermo Brenelli Universidade Estadual de Campinas – Campinas (SP), Brazil.
  • Maria Beatriz de Paula Universidade Estadual de Campinas – Campinas (SP), Brazil.
  • Leite Kraft Universidade Estadual de Campinas – Campinas (SP), Brazil.
  • Cesar Cabello dos Santos Universidade Estadual de Campinas – Campinas (SP), Brazil.
  • Renato Zocchio Torresan Universidade Estadual de Campinas – Campinas (SP), Brazil.
  • Giuliano Mendes Duarte Universidade Estadual de Campinas – Campinas (SP), Brazil.
  • Luiz Carlos Zeferino Universidade Estadual de Campinas – Campinas (SP), Brazil.

DOI:

https://doi.org/10.29289/259453942025V36S10907

Keywords:

breast neoplasms, mastectomy, breast reconstruction, breast conserving surgery, survival analysis

Abstract

Introduction: Surgical choice in breast cancer (extent of oncologic resection and use of reconstruction) is primarily
guided by oncologic safety and patient preference. Prognosis is mainly driven by tumor biology and stage, but perceived
survival differences across surgical techniques persist.
Objective: To compare survival outcomes in patients undergoing breast-conserving surgery (BCS), oncoplastic breastconserving surgery (OBCS), total mastectomy (TM), and immediate breast reconstruction after mastectomy (IBRM).
Methods: This was a retrospective cohort study of consecutive patients with invasive unilateral nonmetastatic breast
cancer treated surgically between 2012 and 2016 at a women’s health center in Brazil. Surgical groups were BCS, OBCS,
TM, and IBRM. Clinicopathological variables, treatments, and outcomes were collected. Survival outcomes were overall survival (OS), disease-free survival (DFS), and breast cancer–specific survival (BCSS), estimated using Kaplan–Meier
methods and compared using Cox regression. Multivariable models were adjusted for age, tumor size, nodal status, and
adjuvant therapy.
Results: Among 1,517 patients, 703 (46.3%) underwent BCS, 104 (6.9%) OBCS, 444 (29.3%) TM, and 266 (17.5%) IBRM. Mean
follow-up was 5.9 years. Five-year OS, DFS, and BCSS were 84.4%, 81.4%, and 89.0%, respectively. In the univariate analysis, compared with BCS, OBCS had inferior DFS (p=0.002) and TM had poorer DFS, BCSS, and OS (all p<0.001). After multivariable adjustment, surgical technique was not independently associated with OS, DFS, or BCSS.
Conclusion: In this large Brazilian cohort of primary unilateral nonmetastatic breast cancer, survival differences observed
across surgical techniques in unadjusted analyses were explained by clinical and treatment factors. Surgical technique
itself was not an independent predictor of survival outcomes.
Ethics: Research Ethics Committee Approval (CAAE 84450518.9.0000.5404).

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Published

2026-10-19

How to Cite

Almeida, N. R., de Azevedo, N. S., Brenelli, F. P., de Paula, M. B., Kraft, L., dos Santos, C. C., … Zeferino, L. C. (2026). 907 – Do surgical techniques influence survival in early breast cancer? A retrospective cohort study of 1,517 patients in Brazil. Mastology, 36(suppl. 1). https://doi.org/10.29289/259453942025V36S10907

Issue

Vol. 36 No. suppl. 1 (2026)

Section

Locoregional Treatment Section

License

Copyright (c) 2026 Natalie Rios Almeida, Nicoli Serquiz de Azevedo, Fabricio Palermo Brenelli, Maria Beatriz de Paula, Leite Kraft, Cesar Cabello dos Santos, Renato Zocchio Torresan, Giuliano Mendes Duarte, Luiz Carlos Zeferino

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.