Association of gemcitabine and cisplatin for metastatic breast câncer after use of anthracyclines
Keywords:
Breast cancer, Chemotherapy, Gemcitabine, Response, ToxicityAbstract
Aim: To eva/uate the response rate, time to progression and toxicity ofthe association of
gemcitabine and cisplatin for metastatic breast câncerpreviousiy treated with anthracyclines.
Patients and methods: Twenty-five patients were induded presenting metastases clinically
and/or radiologically measurab/e. The chemotherapy regimen induded gemcitabine 750mg/m2
and cisplatin 30mg/m2, Dl and D8, every21 days. Resu/ts: A mean of5.2 cydes was performed.
There was complete response in four cases (16%), partial in nine (36%), stable in four(16%)
and progression in eight (32%). The mean and the median time to progression were 32 and 24
weeks, respectively. There was 60% of GI/II hematological toxicity. Grade I gastrointestinal
toxicity occurred in 48% ofthe cases, grade II in 4% and grades III/IV in 12%. Condusion:
The association between gemcitabine and cisplatin showed a good response rate and was well
toierated. Therefore, this regimen shouid be considered as a good option for the patients with
metastatic breast câncer who failed to anthracyclines.
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References
1.BURCH PA, MAILLIARD JA, HILLMAN DW
etal. Phase II study of gemcitabine and
cisplatin in patients with metastatic
breast câncer (MBC) and failure on
prior chemotherapy: a North Central
Câncer Treatment Group Trial. Breast
Câncer Res Treat 2000, 64: 81.
2.CARMICHAEL J, POSSINGER K, PHILLIP P
et a! Advanced breast câncer: a phase
II trial with gemcitabine. J Clin Oncol
1995, 13: 2731-6.
3.CHAUDHRY S, ABDEL-RAHMAN H, PATIL
R et aI. Prospective phase II study of
weekly cisplatin-gemcitabine in
refractory metastatic breast câncer (RMBC). Proc Annu Meet Am Soe Clin Oncol
2000, 19: A430.
4.ELLIS MJ, HAYES DF, LIPPMAN ME.
Treatment of metastatic breast câncer.
In: Harris JR, Lippman ME, Morrow M. Osborne CK. Diseases of the breast,
2. ed. Philadelphia: Lippincott. 2000:
749-97.
5.LOESCH D, ROBERT N, ASMAR L et aI
Phase II multicenter trial of a week
paclitaxel and carboplatin regimen in
patients with advanced breast câncer. J Clin Oncol 2002, 20: 3857-64.
6.NAGOURNEY RA, LINK JS, BLITZER J et
a! Gemcitabine plus cisplatin repeating
doublet therapy in previously treated,
relapsed breast câncer patients. J Clin Oncol 2000, 18: 2245-9.
7.NAGOURNEY RA. Gemcitabine plus
cisplatin in breast câncer. Oncology
2001; 15 (suppl): 28-33.
8.SANAL SM, GOKMEN E, KARABULUT B,
SEZGIN C. Gemcitabine and vinorelbine
combination in patients with metastatic
breast câncer. Breast J 2002; 8: 171-6.
9.STEMMLER J, BISCHOFF J, UNTCH M et
aI Gemcitabine and cisplatin in heavily
pretreated metastatic breast câncer
(MBC). Onkologie 2000; 23 (suppl 7):
60.
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Copyright (c) 2026 Geraldo Silva Queiroz, Ruffo de Freitas Júnior, Luiz Fernando Jubé Ribeiro, Marco Aurélio Costa- Silva
This work is licensed under a Creative Commons Attribution 4.0 International License.
