TINEL LYMPH NODE: IS AN ALTERNATIVE TO THE AXILLARY DISSECTION?
Keywords:
Sentinel lymph node, Breast câncerAbstract
The improvement of early detection breast câncer techniques, mainly through
the screening inammography, has tlie diagnosis of tumors in early stages, without
axillary node involvent. Theoretically, these patients do not benefit from axillary lymph
node dissection, however an accurate staging of breast câncer is essential to guide the
handiling and to determine the prognostic of the disease. The morbidity of axillary
lymph node dissection reaches 30% when studied which emphasis the need of
identifying patients with axillary node positive and precise indication lymphadenectomy. More recently, an alternative has been proposed to lymphadenectomy in early
breast câncer known as sentinel node biopsy (LFNS), defined as the first lymph node
to receive the lymphatic tumor's drainage. LFNS, can be identified through combined methods of lymphatic mapping with radioisotope and coloring biological, is capable to
predict the metastatic status of the axillary and perhaps to avoid lymphadenectomy in most cases.
The proposal of this review is to discuss the advantages and difficulties with this
technique, as well as to demonstrate the association of techniques of lymphatic mapping
to the biopsy of sentinel lymph node, allowing the accurate staging of axillary nodes.
Downloads
References
1.ALBERTINI JJ, LYMAN GH. COX C et al. 8.
Lymphatic mapping and sentinel node biopsy in the
patient with breast câncer. JAMA 1996; 276: 1818-
22.
2.AXELSSON CK, LONTOFT E, BAK M. Sentinel
node - maligmant melanoma and primary breast 9.
câncer. The significance of sentinel node in the treatment of malignant melanoma and primary breast
câncer. Ugeskr Laeger 1999; 161: 2343-7.
3.B ARNWELL JM. ARREDONDO MA, 10.
KOLLMORGEN D et al. Sentinel node biopsy in
breast câncer. Ann Sur Oncol 1998; 5: 126-30.
4.COX CE, PEDAS S, COX JM et al. Guidelines for
sentinel node biopsy and lymphatic mapping of 11.
patients with breast câncer. Ann Sure 1998; 227:
645-51.
5.CSERNI G, BOROSS G, BALTAS B. The role of
the histopathological analsysis of sentinel lymph
nodes in breast câncer. Preliminary findings. Orv 12.
Hetil 1998; 139: 1899-903.
6.DE CICCO C, CHINOL M. PAGANELLI G.
Intraoperative localization of the sentinel node in
breast câncer: technical aspects of lymphoscin- 13.
tigraphic methods. Semin Surg Oncol 1998; 15:
268-71.
7.DE CICCO C, CREMONESI M, LUINI A et al. 14.
Lymphoscintigraphy and radioguided biopy of the
sentinel axillary node in breast câncer. J Nucl Med
1998; 39: 2080-4.
FELDMAN SM, KRAG DN, MCNALLY RK,
MOOR BB, WEAVER DL, KLEIN P. Limitation in
gamma probe localization of sentinel node in breast
câncer patientes with large excisional biopsy. J Am
Coll Surg 1998; 188: 248-54.
GALIMBERTIV, ZURRIDA S, ZUCALIP. LUINI
A. Can sentinel node byopsy avoid axillary
dissection in clinically node-negative breast câncer
patients? Breast J 1998; 7: 8-10.
GIULIANO AE, BARTH AM, SPIVACK B,
BEITSCH PD, EVANS SW. Incident and predictors
of axillary metastasis in TI carcinoma of breas. J
Am Coll Surg 1996; 183; 185-9.
GIULIANO AE, DALE PS, TURNER RR,
MORTON DL, EVANS SW, KRASNE DL.
Improved axillary staging of breast câncer with
sentinel lymphadenectomy. Ann Surg 1995; 222:
394-401.
GIULIANO AE. KIRGAN DM, GUENTHER JM,
MORTON DL. Lymphatic mapping and sentinel
lymphadenectomy for breast câncer. Am Surg
1994; 220: 391-8.
GASS EC, ESSNER R, GIULIANO AE. Sentinel
nodo localization in breast câncer. Semin Nucl Med
1999; 29: 57-68.
GUENTHER JM. KRISHNAMOORTHY M, TAN
LR. Sentinel lymphadenectomy for breast câncerin community managed care stting. Câncer J Sei
1997; 3: 336-40.
15.GULEC S A. MOFFAT FL, CARROLL RG, KRAG
DN. Gamma probe guided sentinel node biopsy in
breast câncer. Q J Nucl Med 1997; 41: 251-61.
16.HILL AD, TRAN KN, AKHURST T et al.
Lessons learned from 500 cases sung of
lymphatic mapping for breast câncer. Ann Surg
1999; 229: 528-35^
17.HOHENBERGER P, REUHL T, MARKWARDT J,
SCHLAG PM. Sentinel node detection in breast
carcinoma. Chirurg 1998; 69: 708-16.
18.HSUEH EC, GIULIANO AE. Sentinel lymph node
technique for staging of breast câncer. Oncoloaist
1998; 3: 165-70.^
19.INTERNATIONAL (LUDWIG) BREAST
CÂNCER STUDY GROUP. Prognostic importance
of occult axillary lymph node micrometastases from
breast cancers. Lancet 1990; 335: 1565-8.
20.KRAG D, WEAVER D, ASHIKAGA T et al. The
sentinel node in breast câncer- a multicenter validation
study. N Engl J Med 1998; 339: 941-6.
21.KRAG DN. WEAVER DL, ALEX JC, FAIRBANK
JT. Sugical resection and radiolocalization of sentinel
lymph node in breast câncer using a gamma probe.
Surg Oncol 1993; 2: 335-9.
22.KUTIYANAWALA MA. SAYED M. STOTTER A.
WINDLE R. REW D. Staging the axilla in breast câncer:
na audit of lymph-node retrival in one UK regional
centre. Eur J Surg Oncol 1998; 24: 280-2.
23.LIBERMAN L, CODY HS. HILL AD et al. Sentinel
lymph node biopsy after percutaneous diagnosis
of nonpalpable breast câncer. Radiology 1999; 211:
835-44.
24.MOORE MP, KINNE DW. Is axillary lymph node
dissection necessary in the routine management of
breast câncer? Yes. Important Adv Oncol 1996;
245-50.
25.MUSTAFA IA, BLAND Kl. Indications for axillary
dissection in TI breast câncer. Am Surg Oncol
1998; 5: 4-8.
26.NIH CONSENSUS DEVELOPMENT COFERENCE.
Treatment of early stage breast câncer. J Natl Câncer
Inst 1992; 11: 1-5.
27.NOUGUCHI M, TSUGAWA K, BANDO E et al.
Sentinel lymphadenectomy in breast câncer:
identification of sentinel lymph node detection of
metastasis. Breast Câncer Res Treat 1999; 53(2):
97-104.
28.ORR RK, HOEHN JL, COL NF. The learning curve
for sentinel node biopsy in breast câncer: practical
considerations. Arch Surg 1999; 134: 764-7.
29.PAGANELLI G. DE CICCO C, CREMONESI M
et al. Optimized sentinel node scintigraphy in breast
câncer. Q J Nucl Med 1998; 42: 49-53.
30.POURQUIER D, LEMANSKIC, FAUROUS P et
al. Câncer of the breast: the return of
lymphadenectomy? Buli Câncer 1998; 85: 675-84.
31.RUERS TJ, ROUMEN RM. No title available. Ned
Tijdschr Geneeskd 1998; 142: 2237-40.
32.TURNER RR, OLLILA DW, KRASNE DL,
GIULIANO AE. Histopathology validation of
sentinel lymph node hypothesis for breast
carcinoma. Ann Surg 1997; 226: 271-6.
33.VALD S, OLMOS RA, JANSEN L. MULLER SH.
HOEFNAGEL CA, NIEWEG O. Contribution of
nuclear medicine to lymphatic mapping and sentinel
node identification in oncology. Ver Esp Med Nucl
1999; 18: 111-21.
34.VAN DIEST PJ, PETERSE HL, BORGSTEIN PJ,
HOEKSTRA O, MIEJER CJ. Pathological
investigation of sentinel lymph nodes. Eur J Nucl
Med 1999; 26: S43-9.
35.VERONESIU, PAGANELLI G, GALIMBERTIV
et al. Sentinel node biopy to avoid axilary dissection
in breast câncer with clinically negative lymph
nodes. Lancet 1997; 349: 1864-7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Kenia Melissa Borghetti, Fabiane S. Barbosa, Maira Caleffi

This work is licensed under a Creative Commons Attribution 4.0 International License.






