Is it possible that there is a relationship between meningioma and the appearance of breast cancer? A systematic review

Abstract

Objective: This study aimed to verify whether there is a relationship between the appearance of breast cancer in patients
previously diagnosed with meningioma. If this relationship is found, this research will also aim to encourage other research to understand the reason for this relationship. Methodology: We comprehensively searched the PubMed database
for case reports and case series that included the incidence of meningioma and patients with the diagnosis of breast cancer in their papers. Our systematic review followed the PRISMA statement guidelines Results: There are more than 49
reported and dated cases of the association between meningioma and breast cancer. Therefore, it is clear that there is an
implicit association between meningiomas and breast carcinoma when we look at these data. Many of these cases occur
during pregnancy, which can lead to a hormonal hypothesis in their genesis. In a bidirectional study, 795,000 patients
were observed who had follow-up for years, in which the standardized incidence ratio was 1.27 for meningioma after a
case of breast cancer; in 28,000 patients, the standardized incidence ratio was 1.32 for breast cancer after meningioma.
However, in a mono-institutionalized study, 12,330 patients were analyzed and only 33 were observed to have meningioma,
presenting a low relational value. Conclusion: It was observed that there is an inconsistency between the numerous clinical cases found and the research carried out, so there is no way to conclude the correlation between the tumors, but
we cannot discard these data. Therefore, further research must be carried out so that we can further improve screening
against these tumors; however, from this review, it is now possible to think of meningioma as a differential diagnosis for
neurological symptoms in patients with breast cancer or a previous history