Multidisciplinary management of adenoid cystic breast carcinoma: case report and literature review

Authors

DOI:

https://doi.org/10.29289/2594539420240036

Keywords:

adenoid cystic carcinoma, multidisciplinary care team, triple-negative breast neoplasms

Abstract

Adenoid cystic carcinoma of the breast is a rare malignant tumor essentially classified as triple-negative for estrogen, progesterone and HER-2 protein receptors. The age range of involvement is from 30 to 90 years, and it is more common in women in the fifth and sixth decades of life. It usually presents as a slow-growing mass, often in the subareolar area, with nonspecific radiological findings. Histopathological diagnosis by puncture biopsy is essential to define the disease. This study aimed to describe the case of a 41-year-old woman with a histopathological diagnosis of breast cancer and report her follow-up and prognosis after breast-conserving surgery and adjuvant therapy. The relevance of the study was based on the rarity of the pathology described in the literature, implying diagnostic difficulties and multidisciplinary management. Thus, clinical, radiological, and histopathological aspects will be discussed in this study, highlighting the importance of multidisciplinary management for the diagnosis and treatment of adenoid cystic carcinoma of the breast, in order to promote better clinical outcomes and reduce morbidity and mortality related to this subtype of breast cancer.

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References

1. Treitl D, Radkani P, Rizer M, El Hussein S, Paramo JC, Mesko TW. Adenoid cystic carcinoma of the breast, 20 years of experience in a single center with review of literature. Breast Cancer. 2018;25(1):28-33. https://doi.org/10.1007/s12282-017-0780-1

2. Elimimian EB, Samuel TA, Liang H, Elson L, Bilani N, Nahleh ZA. Clinical and Demographic Factors, Treatment Patterns, and Overall Survival Associated With Rare Triple-Negative Breast Carcinomas in the US. JAMA Netw Open. 2021;4(4):e214123. https://doi.org/10.1001/jamanetworkopen.2021.4123

3. Liu QQ, Tang LJ, Yan J, Xu Y. Adenoid Cystic Carcinoma of the breast – a case report and review of the literature. Curr Probl Cancer. 2024;15:100309. https://doi.org/10.1016/j.cpccr.2024.100309

4. Zhang W, Fang Y, Zhang Z, Wang J. Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study. Front Oncol. 2021;11:621012. https://doi.org/10.3389/fonc.2021.621012

5. Cima L, Kaya H, Marchiò C, Nishimura R, Wen HY, Fabbri VP, et al. Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses. Virchows Arch. 2021;480(1):109-26. https://doi.org/10.1007/s00428-021-03174-7

6. Foschini MP, Chillotti S, Ciudino R, Fabbri VP, Righi A, Quinn C. Morphological spectrum of adenoid-cystic carcinoma of the breast: focus on diagnostic and prognostic features. Diagn Histopathol. 2022;28(3):142-8. https://doi.org/10.1016/j.mpdhp.2021.12.002

7. Kocaay AF, Celik SU, Hesimov I, Eker T, Percinel S, Demirer S. Adenoid cystic carcinoma of the breast: a clinical case report. Med Arch. 2016;70(5):392-4. https://doi.org/10.5455/medarh.2016.70.392-394

8. Gordillo C, Chukus A. Adenoid cystic carcinoma: A case of rare breast cancer. Radiol Case Rep. 2022;17(3):690-2. https://doi.org/10.1016/j.radcr.2021.12.030

9. World Health Organization (WHO). WHO Classification of Tumours Editorial Board. Breast tumours. 5. ed. Lyon: International Agency for Research on Cancer; 2019 [cited on 2024 Oct 10]. v. 2. Available from: https://publications.iarc.fr/581.

10. Wang S, Li W, Wang F, Niu Y, Hao C, Wang X, et al. 36 cases adenoid cystic carcinoma of the breast in China: Comparison with matched grade one invasive ductal carcinoma-not otherwise specified. Pathol Res Pract. 2017;213(4):310-5. https://doi.org/10.1016/j.prp.2017.01.021

11. Guldogan N, Esen G, Kayadibi Y, Taskin F, Alfatli AO, Boy FNS, et al. Adenoid Cystic Carcinoma of the Breast: Multimodality Imaging Findings and Review of the Literature. Acad Radiol. 2022;30(6):1107-17. https://doi.org/10.1016/j.acra.2022.10.003

12. Marinho ML, Tafuri A, Ramos CAS, Ladeia AAL, Azevedo LC. Adenoid cystic carcinoma of the breast: case report. Mastol. 2021;31:e20210009. https://doi.org/10.29289/2594539420210009

13. Khanfir K, Kallel A, Villette S, Belkacémi Y, Vautravers C, Nguyen T, et al. Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study. Int J Radiat Oncol Biol Phys. 2012;82(5):2118-24. https://doi.org/10.1016/j.ijrobp.2010.12.008

14. Thompson K, Grabowski J, Saltzstein SL, Sadler GR, Blair SL. Adenoid cystic breast carcinoma: is axillary staging necessary in all cases? results from the California Cancer Registry. Breast J. 2011;17(5):485-9. https://doi.org/10.1111/j.1524-4741.2011.01117.x

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Published

2025-11-13

How to Cite

Braga, P. G., Ferreira, A. R. D. P., & Uchoa, A. T. da C. (2025). Multidisciplinary management of adenoid cystic breast carcinoma: case report and literature review. Mastology, 35. https://doi.org/10.29289/2594539420240036

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Section

Case Reports