Carcinoma Intraductal da Mama
Resumo
O autor tece considerações sobre o
carcinoma intraductal (carcinoma ductal
in situ) com referência especial aos
aspectos histológicos e as diversas
formas de tratamento desta neoplasia.
Reconhece a necessidade de dividir o carcinoma intraductal em vários
subtipos de acordo com o grau nuclear.
Dos carcinomas intraductaiso
comedocarcinoma in situé o que apresenta o pior prognóstico. Entre os
fatores que contribuem para a sua
maior agressividade estão o maior
pleomorfismo das células neoplásicas,
indice de proliferação celular, maior
possibilidade de associação com a
invasão oculta e a multicentricidade, o
elevado índice de aneuploidiaea
superexpressão da proteina neu do
oncogene HER-2/neu.
Os diversos subtipos histológicos
de carcinoma intraductal são descritos,
com particular referência ao
comedocarcinoma in situ, carcinoma
micropapilar, carcinoma de células aderentes, carcinoma apócrino com padrão sólido, carcinoma de células claras e carcinoma in situ com padrão de
células em" anel de sinête", carcinoma
cistico hipersecretor.
Downloads
Referências
1. Ashton, MA e Norris, HJ, Breast
chapter 12. In: Pathology of Incipient
Neoplasia. Henseon, DE e AlboresSaavedra, J (eds). Saunders, Filadelfia,
1993
2. Ashikari, R, Hajda, Sl.e Robbins,
Gf. Intracdutal carcinoma of the breast
(1960-1969) Câncer, 28:1182, 1971
3. Azzopardi, JG. Problems in Breast
Pathology. Major Problems in Pathology,
VI 11. Saunders, Filadelfia, 1979
4. Bloodgood, JC. Borderline Breast
Tumors, Ann Surg, 93:235, 1931
5. Bloodgood, JC. Comedocarcinoma
(or comedoadenoma) of femele breast.
Am. J. Câncer, 22:842, 1934
6. Broders, AC. Carcinoma in situ
contrasted with penetrating epithelium,
JAMA 99;1670, 1932
7. Carter, D e Smith, RL. Carcinoma
in situ of. the breast. Cancer, 52:14,
1983
8. Cheatle, GL. Early recognition of
cancer of breast. Br. Med. J1:1205,
1906.9. De Potter, CR, Praet, MM, Slavin,
RE et al. Feulgen DNA content and
mitotic activity in proliferative breast
disease. A comparion with ductal carcinoma in situ. Histopathology, 11:1307,
1987
10. Dervan, PA, Gilmartin, LG, Loftus,
BM,e Carney, DN. Breast carcinoma
Kinetics. Argyrophilic nucleolar
organizer regions counts correlate with
ki 67 scores. Am. J. Clin. Pathol., 92:401,
1989
11. Fischer, ER. The impact of
pathology in Biologic, Diagnostic
Prognostic and Therapeutic
Considerations in breast cancer. Surg
Clin North Amer, 64:1073, 1984
12. Fischer, ER, Saas, R, Fischer, Bet
al.Pathologic findings from the Nat.
Surgical Adjuvant Project (Protocol 6). IIntraductal carcinoma. (DCIS), Cancer 57:197, 1966
13. frykberg, ER, Bland, KIe
Copeland, EM. The detection and
treatment of early breast cancer. In:
Advances in Surgery, vol. 23. Tompkins,
RK (editor). Year Book Medical
Publishers. Chicago, 1990.14. Gump, FE, Shikora, S, Habif, DV
et al. The extent and distribution of
cancer in breast with palpable tumors.
Ann Surg, 204:384, 1986
15. Harris, JR. Clinical Management
of ductal Carcinoma in situ. In:Breast
Disease. Harris, JR, Hellman.
Henderson, IC e Kinne. DW (eds)
Lippincott, New York, 1991
16. Kallioliemi, OP, Blanc, G,
Alavaikko, Met al. Tumor DNA ploidy as
an independent proghnostic factor in
breast câncer. Br. Ca.,56:637, 1987
17. lagios, MD, Westdhal, PR,
Margolin, et al. Duct Carcinoma in situ.
Relationship of extent of noninsive
disease to the frequency of occult
invasion, multicentricity, lymph node
metastases and short-term treament
failures. Câncer 50:1309, 1982
18. Lagios, MD Carcinoma ductal in
situ. Patologia e Tratamento. In: Câncer da Mama em 1990, vl. I Cady, BN
e Bland, Kl (eds). Clin Cirurg Amer
Norte. Interlivros, 1990.
19. lewis, De Geschickter, CF.
Comedocarcinoma of the breast. Arch.
Surg. ,36:225, 1938
20. Rosen, PP, Senie, R.
Schottenfled, D et al. Noninvasive
breast carcinoma. frequency of
unsuspected invasion and implications
for treatment. Ann. Surg, 189:377, 1979
21. Rosen O. Lobular carcinoma in
situ and intraductal carcinoma of the
breast. Monogr Pathol, 25:59, 1984
22. Rosen, PP e Scott, M. Custic
Hupersecretory duct carcinoma of the
breast Amer. J Surg Pathol, 8:31, 1984
23. Schnitt, SJ. Pathology of in situ
carcinoma. In: Breast Diseases. Harris,
JR, Hellman, S Henderson, IC e Kine,
DW. (eds). llppincott, New York, 1991
24. Shap, JP, Rosen, PP, Robbins,
Gf. Pitfalls of local excision in the
treatment of carcinoma of the breast.
Sug. Gynecol obstet, 136:721, 1973.
25. Silvertein, MJ, Rosser, R.
Gienson, Eet al. Intraductal Breast carcinoma (DCIS). A therapeutic dilemma.
Proc. Soc. Clin Oncol, 7:25, 1988
26. Sunshine, JB, Moseley, HS,
Fletcher, WS et al. Breast carcinoma in
situ. A retrospective review of 112
cases with a minimum 10 year followup. Am. J. Surg, 150:44, 1985
27. Tarter, Pl Management of nomplapable breast cancer:Treatment options. In Nonplalpable Breast Cancer.Herman, G, Schwartz, IS e Tarter,
(eds), Igaku-Shoin, N. York, 1992
PI,
28. Travassoli, FA. Pathology of the
Breast. Elsevier, New York. 1992
29. Tinnemans, JGM, Webber, T,
Van der Sluis, Rf et al. Multicentricity in
non-palpable breast carcinoma and its
implicatin for treatment. Am. J. Surg,
151:334, 1986
30. Tuluson, AB, Romay, G, Egger, Н
et al. A contribution to the natural
history of breast cancer. V. Bilateral
primary breast cancer:incidence, risks
and diagnosis of simultaneous primary
cancer in the oposite breast. ArchGynecol 237:85, 1985
31. Von Reuden DG, Wilson, RE.
Intraductal carcinoma of the breast.
Surg. Guneco Obstet, 158:105, 1984
32. Westbrook, KC, Gallager, HS.
Intraductal carcinoma of breast. A
comparative studų. Am. J. Surg, m
85:791, 1962
33. Webber, BL, Heise, N, Neifelt, JP
et al. Risk of subsequent contralateral
breast carcinoma in a populatin of
patiens with in situ carcinoma, Cancer,
47:2928 1981.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2026 Ely Chaves
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
