Aplicação do índice prognóstico de Nottingham em pacientes com câncer de mama atendidas em um hospital público

Application of the Nottingham prognosis index in breast cancer patients treated at a public hospital

Authors

  • Miguel Angelo Spinelli Varella Mestre em Ciências Médicas da Universidade Federal do Rio Grande do Sul (UFRGS). Mastologista (TEMA) e cirurgião-geral do Hospital Femina.
  • James Freitas Fleck Professor-doutor da UFRGS. Oncologista clínico.
  • Paulo Pinto Machado Mastologista do Hospital Femina.
  • João Batista Andreola Mastologista do Hospital Femina
  • Pablo Varella Goulart Acadêmico de Medicina da Pontifícia Universidade Católica do Rio Grande do Sul (PUC-RS).

Keywords:

Mammary neoplasias, Prognostic factors, Breast cancer

Abstract

A history cohort study that included 116 breast cancer patients treated at the Femina Hospital, Grupo
Hospitalar Conceição (GHC), Health Ministry (HM), between September 1997 to December 2000 was
conducted. The Nottingham Prognostic Index (NPI) and its association with the disease recidivation
was assessed in the study population. The NPI identified two groups; good prognosis group (n = 26) with
7.7% recidivation and a poor prognosis group (n = 32) with 75% recidivation at 5 years. The tumor
size in our study population was 3.1 ± 1.8 cm and it was less than 2 cm in only 25% of the patients at
the first consultation at a tertiary hospital. These observations suggested that the breast cancer diagnosis is
performed late in our environment.

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References

1. Galea MH, Blamey RW, Elston CE, Ellis IO. The Nottingham

prognostic index in primary breast cancer. Breast Cancer Res Treat. 1992;22:207-19.

2. Abreu E, Koifman S. Fatores prognósticos em câncer de mama

feminina. Rev Bras Cancerol. 2002;48(1):113-31.

3. Veronese U, Cascinelli N, Mariani L, Greco M. Twenty-year

follow-up of a randomised study comparing breast-conserving

surgery with radical mastectomy for early breast cancer. N Engl J

Med. 2002;347:1227-32.

4. Okugawa H, Yamamoto D, Uemura Y, Sakaida N, Yamada М,

Tanaka K, et al. Prognostic factors in breast cancer: the value of

the Nottingham prognostic index for patients treated in a single

institution. Surg Today. 2005;35:907-11.5. Haybittle JL, Blamey RW, Elston CW, Johnson J, Doyle PJ, Campbell FC, et al. A prognostic index in primary breast cancer. Br J

Cancer. 1982;45:361-6.

6. Mendonça GAS, Silva AM, Caula WM. Características tumorais e

sobrevida de cinco anos em pacientes com câncer de mama admitidas no instituto nacional do câncer. Rio de Janeiro, Brasil. Cad

Saúde Pública. 2004;20(5):1232-9.

7. Joslyn AS, Konety BR. Effect of axillary lymphadenectomy on breast carcinoma survival. Breast Cancer Res Treat. 2005;91:11-8.

8. Hansen NM, Ye X, Grube BJ, Giuliano AE. Manipulation of the

primary breast tumor and the incidence of sentinel node metastases from invasive breast cancer. Arch Surg. 2004;139(6):634-40.

9. D'Eredita G, Giardina C, Marttellotta M, Natale T, Ferrarese F. Prognostic factors in breast cancer: the predictive value of

the Nottingham prognostic index in patients with a long-term

follow-up that were treated in a single institution. Eur J Cancer.

2001:37:591-6.

10. Prado CBP. Da cirurgia de Halsted à biópsia do linfonodo sentinela. Rev Ginecol Obstet. 2004;15(4):245-8.

11. Wang Y, Klijn JGM, Zhang Y, Sieuwerts AM, Look MP, Yang F, et

al. Gene-expression profiles to predict distant metastasis oflymphnode-negative primary breast cancer. Lancet. 2005;365:671-9.

12. Aapro MS. Adjuvant therapy of primary breast cancer: a rewiew of

key findings from the seventh internacional conference, St Gallen,

february 2001. Oncologist. 2001;6:376-85.

13. Todd JH, Dowle C, Williams MR, Elston CW, Ellis IO, Hinton

CP, et al. Confirmation of a prognostic index in a primary breast

cancer. Br J Cancer. 1987;56:489-92.

14. Melo e Silva D, Saddi VA, Momotuk EG. Marcadores moleculares associados ao câncer de mamma. Rev Bras Cancerol. 2002;48(1):39-48.

15. Maia EMC, Maia LB, Valente FM, Machado RB, Borges JBR.

Tempo decorrido entre a primeira consulta e o tratamento definitivo nos casos de câncer de mama no sistema de saúde público da

cidade de Jundiaí. Rev Bras Mastol. 2006;1:23-6.

16. Paajanen H, Kyhala L, Varjo R, Rantala S. Effect of screening

mammografy on the surgery of breast cancer in Finland: a population-based analysis during the years 1985-2004. Am Surg.

2006;72(2):167-71.

17. Harris R. Effectiveness: the next question for breast cancer screening. J Natl Cancer Instit. 2005;97:1021-3.

18. McShane LM, Altman DG, Sauerbrei W. Identification of clinically useful cancer prognostic factors: What are we missing? J Natl

Cancer Instit. 2005;97(14):1023-5.

19. Brasil. Ministério da Saúde. Instituto Nacional do Câncer. Estimativas da incidência e mortalidade por câncer no Brasil 2006;

[acesso em 2006 sep 15]. Disponível em: http://www.inca.gov.br/

estimativas/2006/.

20. Ramos Filho AOA, Castro TWN, Rego MAV, Alves FO, Almeida

LC, Souza MV, et al. Fatores preditivos de recidiva do carcinoma

mamário axila-negativo. Rev Bras Cancerol. 2002;48(4):499-503.

Published

2026-07-26

How to Cite

Varella, M. A. S., Fleck, J. F., Machado, P. P., Andreola, J. B., & Goulart, P. V. (2026). Aplicação do índice prognóstico de Nottingham em pacientes com câncer de mama atendidas em um hospital público: Application of the Nottingham prognosis index in breast cancer patients treated at a public hospital. Revista Brasileira De Mastologia, 18(1). Retrieved from https://mastology.org/rbm/article/view/2018

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